Article
Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer's disease.
Human genetics - 1 Jul 2018
Yamaguchi-Kabata Yumi, Morihara Takashi, Ohara Tomoyuki, Ninomiya Toshiharu, Takahashi Atsushi, Akatsu Hiroyasu, Hashizume Yoshio, Hayashi Noriyuki, Shigemizu Daichi, Boroevich Keith A, Ikeda Manabu, Kubo Michiaki, Takeda Masatoshi, Tsunoda Tatsuhiko
Abstract excerpt
Alzheimer's disease (AD) is a common neurological disease that causes dementia in humans. Although the reports of associated pathological genes have been increasing, the molecular mechanism leading to the accumulation of amyloid-β (Aβ) in human brain is still not well understood. To identify novel genes that cause accumulation of Aβ in AD patients, we conducted an integrative analysis by combining a human genetic...
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