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Genetic deletion of Bco2 and Isx establishes a golden mouse model for carotenoid research

22 May 2023

Abstract excerpt

Low plasma levels of carotenoids are associated with mortality and chronic disease states. Genetic studies in animals revealed that the tissue accumulation of these dietary pigments is associated with the genes encoding β-carotene oxygenase 2 (BCO2) and the scavenger receptor class B type 1 (SR-B1). Here we examined in mice how BCO2 and SR-B1 affect the metabolism of the model carotenoid zeaxanthin that serves as...

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PMID: 37225015
DOI: 10.1016/j.molmet.2023.101742

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