Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease.

British journal of haematology - 1 Jun 2020

Rashidi Armin, Herman Adam, Gomes Antonio L C, Peled Jonathan U, Jenq Robert R, Brereton Daniel G, Staley Christopher, Blazar Bruce R, Weisdorf Daniel J

Abstract excerpt

We previously reported a protective association between single nucleotide polymorphisms (SNPs; rs4415345G and rs4610776A alleles) of Paneth cell α-defensin-5 against acute graft-versus-host disease (aGVHD). Because dysbiosis has been associated with aGVHD, we hypothesized that these SNPs may have a gut microbiota signature. In Lasso regression analysis of 248 healthy individuals, rs4415345G was associated with a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allografts
Share to alpha-Defensins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacteroidetes

Share to Cord Blood Stem Cell Transplantation

Share to Dysbiosis

Share to Graft vs Host Disease

Share to Metagenome

Share to Paneth Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 32086815
DOI: 10.1111/bjh.16458
PMCID: PMC7536617

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease.PMID 32086815Read ↗

Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples.Semantic proximity Read ↗

Functional and phylogenetic alterations in gut microbiome are linked to graft-versus-host disease severitySemantic proximity Read ↗

Specific gut microbiome members are associated with distinct immune markers in pediatric allogeneic hematopoietic stem cell transplantationSemantic proximity Read ↗

Commensal Oral Microbiota Influences Ulcerative Oral Mucositis Clinical Course in Allogeneic Stem Cell Transplant RecipientsSemantic proximity Read ↗

Alteration of Gut Microbiota Composition and Diversity in Acute and/or Chronic Graft-versus-Host Disease Following Hematopoietic Stem Cell Transplantation: A Prospective Cohort StudySemantic proximity Read ↗

Enterococcus: A Predictor of Ravaged Microbiota and Poor Prognosis after Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity Read ↗

Microbiota long-term dynamics and prediction of acute graft-versus-host disease in pediatric allogeneic stem cell transplantationSemantic proximity Read ↗

Anaerobic Antibiotics and the Risk of Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell TransplantationSemantic proximity Read ↗

Disruption of the oral microbiota is associated with a higher risk of relapse after allogeneic hematopoietic stem cell transplantationSemantic proximity Read ↗

Gut microbiota diversity before allogeneic hematopoietic stem cell transplantation as a predictor of mortality in childrenSemantic proximity Read ↗

Dental biofilm microbiota dysbiosis is associated with the risk of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantationSemantic proximity Read ↗

Host NLRP6 exacerbates graft-versus-host disease independent of gut microbial compositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.