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Article

Allele-specific methylation contributed by CpG-SNP is associated with regulation of ALOX5AP gene expression in ischemic stroke.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Oct 2018

Shi Yunshu, Xu Liyan, Feng Qingchuan, Li Aifan, Jia Jing, Xu Yan, Yang Dongzhi, Zhang Yuchao, Zhang Xuran, Zhao Huiling, Wang Jun, He Ying, Zheng Hong

Abstract excerpt

Previous studies have shown that CpG-SNPs might have influence on gene function via allele-specific DNA methylation (ASM). However, association study between DNA methylation and the promoter CpG-SNPs in ALOX5AP gene with IS has not been reported. The present study aims to explore the relationship among CpG-SNPs, methylation levels, and messenger RNA (mRNA) expression levels of ALOX5AP gene. Firstly, we made a...

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PMID: 30003372
DOI: 10.1007/s10072-018-3489-9

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