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A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Jan 2000

Kim Dong Hwan, Ahn Woo Yong, Kim Dong Kwan, Choe Bong Keun, Kim Su Kang, Jo Dae Jean, Kim Jae Young, Chung Joo-Ho, Jeong Yong Seol, Yun Dong Hwan, Yoo Seung Don, Kim Hee-Sang, Baik Hyung Hwan

Abstract excerpt

To investigate whether single nucleotide polymorphisms (SNPs) of eicosanoid biosynthesis genes are associated with intracerebral hemorrhage (ICH) and ischemic stroke (IS), seven SNPs in the coding or promoter regions were selected: ALOX12 (rs434473, Asn322Ser), ALOX5 (rs2228064, Thr90Thr), ALOX5AP (rs17222919, -1316T/G), PTGES (rs7872802, -404A/G), PTGIS (rs5628, Leu256Leu), PTGS1 (, Gln41Gln) and PTGS2...

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Identifiers

PMID: 21816595
DOI: 10.1016/j.plefa.2011.07.004

Genes

ALOX12
ALOX5
PTGES
PTGIS
PTGS1
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population.PMID 21816595Read ↗

Comment on: "A promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population" by Hwan Kim D. et al. [Prostaglandins Leukot. Essent. Fatty Acids 85 (2011) 115-120].Semantic proximity Read ↗

A promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP gene is associated with decreased risk of ischemic stroke in two independent Chinese populations.Semantic proximity Read ↗

Genetic Variants in the Transcriptional Regulatory Region of the ALOX5AP gene and Susceptibility to Ischemic Stroke in Chinese Populations.Semantic proximity Read ↗

Genetic variants in the promoter region of the ALOX5AP gene and susceptibility of ischemic stroke.Semantic proximity Read ↗

A novel risk haplotype of ALOX5AP gene is associated with ischemic stroke in Chinese Han population.Semantic proximity Read ↗

Association Between Paraoxonase Gene Polymorphisms and Intracerebral Hemorrhage in a Korean Population.Semantic proximity Read ↗

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene rs4073259 polymorphism not associated with ischemic stroke in the northeastern Chinese Han population.Semantic proximity Read ↗

Ischemic Stroke and Six Genetic Variants in CRP, EPHX2, FGA, and NOTCH3 Genes: A Meta-Analysis.Semantic proximity Read ↗

Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese.Semantic proximity Read ↗

Variants in the Atherogenic ALOX5AP, THBD, and KNG1 Genes Potentiate the Risk of Ischemic Stroke via a Genetic Main Effect and Epistatic Interactions in a Chinese Population.Semantic proximity Read ↗

Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.Semantic proximity Read ↗

Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies.Semantic proximity Read ↗

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