Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study.

doi:10.1159/000302738

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Article

Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2010

Domingues-Montanari Sophie, Fernández-Cadenas Israel, del Rio-Espinola Alberto, Corbeto Natalia, Krug Tiago, Manso Helena, Gouveia Liliana, Sobral Joao, Mendioroz Maite, Fernández-Morales Jessica, Alvarez-Sabin José, Ribó Marc, Rubiera Marta, Obach Victor, Martí-Fàbregas Joan, Freijo Marimar, Serena Joaquin, Ferro José M, Vicente Astrid M, Oliveira Sofia A, Montaner Joan

Abstract excerpt

BACKGROUND: Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) through whole-genome linkage screens. However, association studies obtained conflicting results. We aimed to investigate the contribution of selected single nucleotide polymorphisms (SNPs) in these genes for the first time in a large Iberian...

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PMID: 20357438
DOI: 10.1159/000302738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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