DNA Methylation and SNPs of ABCA1 Gene Promoter Affect Gene Expression and Involve in the Pathological Mechanism of Ischemic Stroke

Abstract excerpt

<title>Abstract</title> <p>ATP binding cassette subfamily A1 (ABCA1) is a key protein in the formation of mature high density lipoprotein (HDL), which plays a crucial role in atherosclerosis. Accumulating evidence has shown that the expression levels of the <italic>ABCA1</italic> gene are upregulated in ischemic stroke (IS) patients. However, the mechanism remains elusive. We hypothesized that DNA methylation and...

Topics

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• ATP Binding Cassette Transporter 1
• ATP Binding Cassette Transporter, Subfamily G, Member 1
• CpG Islands
• DNA Methylation
• Epigenesis, Genetic
• Incidence
• Odds Ratio
• Stroke

Identifiers and source

Literature Corpus work

b95e67dd-a6ec-509d-86bf-a2624629f515

DOI

10.21203/rs.3.rs-998653/v1