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Article

Neuropsychiatric manifestations among HIV-1 infected African patients receiving efavirenz-based cART with or without tuberculosis treatment containing rifampicin.

European journal of clinical pharmacology - 1 Nov 2018

Mugusi Sabina, Ngaimisi Eliford, Janabi Mohammed, Mugusi Ferdinand, Minzi Omary, Aris Eric, Bakari Muhammad, Bertilsson Leif, Burhenne Juergen, Sandstrom Eric, Aklillu Eleni

Abstract excerpt

PURPOSE: Efavirenz-based combination antiretroviral therapy (cART) is associated with neuropsychiatric adverse events. We investigated the time to onset, duration, clinical implications, impact of pharmacogenetic variations, and anti-tuberculosis co-treatment on efavirenz-associated neuropsychiatric manifestations. METHODS: Prospective cohort study of cART naïve HIV patients with or without tuberculosis (HIV-TB)...

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Identifiers

PMID: 30003275
DOI: 10.1007/s00228-018-2499-0
PMCID: PMC6182598

Genes

ABCB1

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