Article

Assessment of CFTR Dysfunction and Responsiveness to CFTR Modulators in COPD Bronchial Air‐Liquid Interface Cultures

2026-06-23

Abstract excerpt

Increasing evidence suggests that acquired dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel occurs as a result of cigarette smoke exposure in Chronic obstructive pulmonary disease (COPD). CFTR-targeted therapies were developed for the treatment of genetic CFTR defects in cystic fibrosis, but they have not demonstrated consistent clinical efficacy in small trials of patients...

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Literature Corpus work: aac2a47d-2342-56c5-a45f-7a1d454bd087
DOI: 10.20944/preprints202606.1673.v1

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