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Article

RIG-I Recognizes the 5′ Region of Dengue and Zika Virus Genomes

1 Jul 2018

Abstract excerpt

The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika (ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition receptors that are implicated in detecting viral RNAs. Here, we show that RNAs that co-purified with RIG-I during DENV infection are immuno-stimulatory, whereas RNAs bound to MDA5 are not. An affinity purification method combined with next-generation...

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PMID: 29996094
DOI: 10.1016/j.celrep.2018.06.047

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