Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I

Abstract excerpt

UNLABELLED: Stimulation of the antiviral response depends on the sensing of viral pathogen-associated molecular patterns (PAMPs) by specialized cellular proteins. During infection with RNA viruses, 5'-di- or -triphosphates accompanying specific single or double-stranded RNA motifs trigger signaling of intracellular RIG-I-like receptors (RLRs) and initiate the antiviral response. Although these molecular...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to interferon and immune responses
• Share to Respiratory viral infections research
• Share to RNA regulation and disease