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Article

Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56+ T cells.

American journal of physiology. Renal physiology - 1 Sept 2018

Uchida Takahiro, Nakashima Hiroyuki, Ito Seigo, Ishikiriyama Takuya, Nakashima Masahiro, Seki Shuhji, Kumagai Hiroo, Oshima Naoki

Abstract excerpt

Although activation of mouse natural killer T (NKT) cells by α-galactosylceramide (α-GalCer) causes failure of multiple organs, including the kidneys, the precise mechanisms underlying kidney injury remain unclear. Here, we showed that α-GalCer-activated mouse NKT cells injured both kidney vascular endothelial cells and tubular epithelial cells in vitro, causing acute kidney injury (AKI) with hematuria in...

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Identifiers

PMID: 29993279
DOI: 10.1152/ajprenal.00160.2018
PMCID: PMC6172573

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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