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Article

NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.

Journal of leukocyte biology - 1 Mar 2015

Spada Roberto, Rojas José M, Pérez-Yagüe Sonia, Mulens Vladimir, Cannata-Ortiz Pablo, Bragado Rafael, Barber Domingo F

Abstract excerpt

NK cells are a major component of the immune system, and alterations in their activity are correlated with various autoimmune diseases. In the present work, we observed an increased expression of the NKG2D ligand MICA in SLE patients' kidneys but not healthy subjects. We also show glomerulus-specific expression of the NKG2D ligands Rae-1 and Mult-1 in various murine SLE models, which correlated with a higher...

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Identifiers

PMID: 25583577
DOI: 10.1189/jlb.4A0714-326R
PMCID: PMC5477896

Genes

MICA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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