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Article

RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.

Scientific reports - 27 Jul 2020

Richter Lukas, Oberländer Viktoria, Schmidt Gudula

Abstract excerpt

Rho GTPases are important regulators of many cellular functions like cell migration, adhesion and polarity. The molecular switches are often dysregulated in cancer. We detected Rho-dependent upregulation of the orphan seven-transmembrane receptor G-protein-coupled receptor family C group 5 member A (GPRC5A). GPRC5A is highly expressed in breast cancer whereas in lung cancer, it is often downregulated. Here, we...

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Identifiers

PMID: 32719397
DOI: 10.1038/s41598-020-69481-2
PMCID: PMC7385118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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