Article
RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.
Scientific reports - 27 Jul 2020
Richter Lukas, Oberländer Viktoria, Schmidt Gudula
Abstract excerpt
Rho GTPases are important regulators of many cellular functions like cell migration, adhesion and polarity. The molecular switches are often dysregulated in cancer. We detected Rho-dependent upregulation of the orphan seven-transmembrane receptor G-protein-coupled receptor family C group 5 member A (GPRC5A). GPRC5A is highly expressed in breast cancer whereas in lung cancer, it is often downregulated. Here, we...
Topics
- Cell Division
- Cell Line, Tumor
- Cell Proliferation
- Down-Regulation
- Epidermal Growth Factor
- Epithelial Cells
- ErbB Receptors
- Humans
- Ligands
- Models, Biological
- Mutation
- Phosphorylation