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Article

Frequent Inactivation of RAMP2, EFEMP1 and Dutt1 in Lung Cancer by Promoter Hypermethylation

1 Aug 2007

Abstract excerpt

PURPOSE: The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer. EXPERIMENTAL DESIGNS: Bioinformatic analysis was done to identify candidate genes significantly down-regulated in lung cancer. The effects of DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine on the expression of the candidate genes were determined. Methylated CpG sites in the promoters...

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PMID: 17671114
DOI: 10.1158/1078-0432.ccr-07-0015

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