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Genetic Analysis of Neurite Outgrowth Inhibitor-Associated Genes in Parkinson's Disease: A Cross-Sectional Cohort Study.

CNS neuroscience & therapeutics - 1 Oct 2024

Huang Xiurong, Wang Yige, Xiang Yaqin, Zhao Yuwen, Pan Hongxu, Liu Zhenhua, Xu Qian, Sun Qiying, Tan Jieqiong, Yan Xinxiang, Li Jinchen, Tang Beisha, Guo Jifeng

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disease caused by a combination of aging, environmental, and genetic factors. Previous research has implicated both causative and susceptibility genes in PD development. Nogo-A, a neurite outgrowth inhibitor, has been shown to impact axon growth through ligand-receptor interactions negatively, thereby involved in the deterioration of dopaminergic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39354865
DOI: 10.1111/cns.70070
PMCID: PMC11445604

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