APOL1 risk genotype in European steroid-resistant nephrotic syndrome and/or focal segmental glomerulosclerosis patients of different African ancestries.

doi:10.1093/ndt/gfy176

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APOL1 risk genotype in European steroid-resistant nephrotic syndrome and/or focal segmental glomerulosclerosis patients of different African ancestries.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Nov 2019

Gribouval Olivier, Boyer Olivia, Knebelmann Bertrand, Karras Alexandre, Dantal Jacques, Fourrage Cécile, Alibeu Olivier, Hogan Julien, Dossier Claire, Tête Marie Josèphe, Antignac Corinne, Servais Aude

Abstract excerpt

BACKGROUND: Apolipoprotein L1 (APOL1) risk variants are strongly associated with sporadic focal segmental glomerulosclerosis (FSGS) in populations with African ancestry. We determined the frequency of G1/G2 variants in steroid-resistant nephrotic syndrome (SRNS)/FSGS patients with African or French West Indies ancestry in France and its relationships with other SRNS genes. METHODS: In a cohort of 152 patients...

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PMID: 29992269
DOI: 10.1093/ndt/gfy176

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APOL1

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