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Article

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway.

Cancer medicine - 1 Aug 2018

Zhou Yun, Que Ke-Ting, Zhang Zhen, Yi Zu J, Zhao Ping X, You Yu, Gong Jian-Ping, Liu Zuo-Jin

Abstract excerpt

PURPOSE: Macrophages play critical roles in inflammation and wound healing and can be divided into two subtypes: classically activated (M1) and alternatively activated (M2) macrophages. Macrophages also play important roles in regulating iron homeostasis, and intracellular iron accumulation induces M1-type macrophage polarization which provides a potential approach to tumor immunotherapy through M2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29989329
DOI: 10.1002/cam4.1670
PMCID: PMC6089144

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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