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Article

Apolipoprotein E deficiency leads to the polarization of splenic macrophages towards M1 phenotype by increasing iron content.

Genes and immunity - 1 Oct 2024

Shen Meng-Qi, Guo Qian, Li Wei, Qian Zhong-Ming

Abstract excerpt

Apolipoprotein E (ApoE) plays a crucial role in iron homeostasis in the body, while macrophages are the principal cells responsible for handling iron in mammals. However, it is unknown whether ApoE can affect the functional subtypes and the iron handling capacity of splenic macrophages (SM). Here, we investigated the effects of ApoE deficiency (ApoE-/-) on the polarization and iron content of SM and its potential...

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Identifiers

PMID: 39103538
DOI: 10.1038/s41435-024-00290-7

Genes

CD86
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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