Article
Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression.
PloS one - 1 Jan 2016
Mertens Christina, Akam Eman Abureida, Rehwald Claudia, Brüne Bernhard, Tomat Elisa, Jung Michaela
Abstract excerpt
A growing body of evidence suggests that macrophage polarization dictates the expression of iron-regulated genes. Polarization towards iron sequestration depletes the microenvironment, whereby extracellular pathogen growth is limited and inflammation is fostered. In contrast, iron release contributes to cell proliferation, which is important for tissue regeneration. Moreover, macrophages constitute a major...
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