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Article

Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease

22 Jun 2018

Abstract excerpt

Alzheimer's disease (AD) is the most common form of dementia, with over 5. 4 million cases in the US alone (Alzheimer's Association, 2016). Clinically, AD is defined by the presence of plaques composed of Aβ and neurofibrillary pathology composed of the microtubule associated protein tau. Another key feature is the dysregulation of autophagy at key steps in the pathway. In AD, disrupted autophagy contributes to...

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PMID: 29988365
DOI: 10.3389/fnins.2018.00372

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