Effect of Mutations on the Global and Site-Specific Stability and Folding of an Elementary Protein Structural Motif.

Abstract excerpt

Understanding the folding mechanism of proteins requires detailed knowledge of the roles of individual amino acid residues in stabilization of specific elements and local segments of the native structure. Recently, we have utilized the combination of circular dichroism (CD) and site-specific 13C isotopically edited infrared spectroscopy (IR) coupled with the Ising-like model for protein folding to map the thermal...

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