Article
Hypertrophy Regression With N-Acetylcysteine in Hypertrophic Cardiomyopathy (HALT-HCM): A Randomized, Placebo-Controlled, Double-Blind Pilot Study.
Circulation research - 13 Apr 2018
Marian Ali J, Tan Yanli, Li Lili, Chang Jeffrey, Syrris Petros, Hessabi Manouchehr, Rahbar Mohammad H, Willerson James T, Cheong Benjamin Y, Liu Chia-Ying, Kleiman Neal S, Bluemke David A, Nagueh Sherif F
Abstract excerpt
RATIONALE: Hypertrophic cardiomyopathy (HCM) is a genetic paradigm of cardiac hypertrophy. Cardiac hypertrophy and interstitial fibrosis are important risk factors for sudden death and morbidity in HCM. Oxidative stress is implicated in the pathogenesis of cardiac hypertrophy and fibrosis. Treatment with antioxidant N-acetylcysteine (NAC) reverses cardiac hypertrophy and fibrosis in animal models of HCM....
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