Article
Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis.
Cancer genetics and cytogenetics - 15 Jul 2006
Athanasiadou Anastasia, Stamatopoulos Kostas, Tsompanakou Aliki, Gaitatzi Maria, Kalogiannidis Panagiotis, Anagnostopoulos Achilles, Fassas Athanasios, Tsezou A
Abstract excerpt
In a cohort of 130 unselected chronic lymphocytic leukemia (CLL) patients, 73 cases had normal karyotypes, 57 cases had abnormal karyotypes, and 22/57 cases carried more than one abnormality. Trisomy 12 (+12) was the most common abnormality (26/130 cases; 20%), and 17/26 cases had isolated +12. Del(13q)/t13q/-13 was detected in 19/130 cases (14.6%), and 5/19 cases had isolated del(13)(q12q14). Deletion (11)(q23)...
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