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Article

Mediation analysis to understand genetic relationships between habitual coffee intake and gout.

Arthritis research & therapy - 5 Jul 2018

Hutton Joseph, Fatima Tahzeeb, Major Tanya J, Topless Ruth, Stamp Lisa K, Merriman Tony R, Dalbeth Nicola

Abstract excerpt

BACKGROUND: Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2 genes have been associated with both reduced coffee intake and increased serum urate in separate genome-wide association studies (GWAS). The aim of this study was to determine whether these single nucleotide polymorphisms (SNPs) influence the...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 29976226
DOI: 10.1186/s13075-018-1629-5
PMCID: PMC6034252

Genes

ABCG2
GCKR
MLXIPL

Provenance

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