Article
The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders.
Human genetics - 1 Mar 2010
Furusawa Takuro, Naka Izumi, Yamauchi Taro, Natsuhara Kazumi, Kimura Ryosuke, Nakazawa Minato, Ishida Takafumi, Inaoka Tsukasa, Matsumura Yasuhiro, Ataka Yuji, Nishida Nao, Tsuchiya Naoyuki, Ohtsuka Ryutaro, Ohashi Jun
Abstract excerpt
Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin gene (LEP), G-2548A (rs7799039), and two non-synonymous single nucleotide polymorphisms of the leptin receptor gene (LEPR), K109R (rs1137100) and Q223R (rs1137101), with body weight, body mass index (BMI) and obesity (BMI >...
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