Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Variance explained by whole genome sequence variants in coding and regulatory genome annotations for six dairy traits.

BMC genomics - 5 Apr 2018

Koufariotis Lambros T, Chen Yi-Ping Phoebe, Stothard Paul, Hayes Ben J

Abstract excerpt

BACKGROUND: There are an exceedingly large number of sequence variants discovered through whole genome sequencing in most populations, including cattle. Deciphering which of these affect complex traits is a major challenge. In this study we hypothesize that variants in some functional classes, such as splice site regions, coding regions, DNA methylated regions and long noncoding RNA will explain more variance in...

Topics

Animals
Cattle
Female
Fertility
Gene Frequency
Gene Regulatory Networks
Genetic Variation
Molecular Sequence Annotation
Pregnancy
Quantitative Trait Loci
RNA Splice Sites

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 29618315
DOI: 10.1186/s12864-018-4617-x
PMCID: PMC5885354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variance explained by whole genome sequence variants in coding and regulatory genome annotations for six dairy traits.PMID 29618315Read ↗

Regulatory and coding genome regions are enriched for trait associated variants in dairy and beef cattle.Semantic proximity Read ↗

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traitsSemantic proximity Read ↗

Rare Variants in Transcript and Potential Regulatory Regions Explain a Small Percentage of the Missing Heritability of Complex Traits in Cattle.Semantic proximity Read ↗

Variance component estimates for growth traits in beef cattle using selected variants from imputed low-pass sequence data.Semantic proximity Read ↗

Bayesian genome-wide analysis of cattle traits using variants with functional and evolutionary significanceSemantic proximity Read ↗

Genome variants associated with RNA splicing variations in bovine are extensively shared between tissues.Semantic proximity Read ↗

Pangenome-based structural variant imputation enables large-scale genotype-phenotype studies in dairy cattle.Semantic proximity Read ↗

Invited review: Good practices in genome-wide association studies to identify candidate sequence variants in dairy cattle.Semantic proximity Read ↗

Targeted imputation of sequence variants and gene expression profiling identifies twelve candidate genes associated with lactation volume, composition and calving interval in dairy cattle.Semantic proximity Read ↗

Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations.Semantic proximity Read ↗

Deep sequencing of Danish Holstein dairy cattle for variant detection and insight into potential loss-of-function variants in protein coding genes.Semantic proximity Read ↗

Evaluation of variant identification methods for whole genome sequencing data in dairy cattle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.