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Article

Rapid, Reliable, and Inexpensive HLA-B*58:01 Detection Method Using DNA Binding Dye-based Duplex Allele-specific Melting Curve Analysis.

Annals of clinical and laboratory science - 1 May 2018

Huh Ji Young, Han Ok Jin, Park Geon

Abstract excerpt

BACKGROUND: Allopurinol is the most commonly used drug for the treatment of gout and also one of the most common causes of severe cutaneous adverse reactions (SCARs). Human leukocyte antigen-B*58:01 (HLA-B*58:01) is strongly associated with allopurinol-induced SCARs. The aim of the present study was to develop and validate a rapid and economic screening method for HLA-B*58:01. METHODS: The accuracy of duplex...

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PMID: 29970431

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