Article
Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.
Nature medicine - 1 Aug 2018
Vinci Mara, Burford Anna, Molinari Valeria, Kessler Ketty, Popov Sergey, Clarke Matthew, Taylor Kathryn R, Pemberton Helen N, Lord Christopher J, Gutteridge Alice, Forshew Tim, Carvalho Diana, Marshall Lynley V, Qin Elizabeth Y, Ingram Wendy J, Moore Andrew S, Ng Ho-Keung, Trabelsi Saoussen, H'mida-Ben Brahim Dorra, Entz-Werle Natacha, Zacharoulis Stergios, Vaidya Sucheta, Mandeville Henry C, Bridges Leslie R, Martin Andrew J, Al-Sarraj Safa, Chandler Christopher, Sunol Mariona, Mora Jaume, de Torres Carmen, Cruz Ofelia, Carcaboso Angel M, Monje Michelle, Mackay Alan, Jones Chris
Abstract excerpt
The failure to develop effective therapies for pediatric glioblastoma (pGBM) and diffuse intrinsic pontine glioma (DIPG) is in part due to their intrinsic heterogeneity. We aimed to quantitatively assess the extent to which this was present in these tumors through subclonal genomic analyses and to determine whether distinct tumor subpopulations may interact to promote tumorigenesis by generating subclonal...
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