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Article

Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma

15 Mar 2019

Abstract excerpt

Abstract Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses showed that all diagnostic and recurrent samples were collections of genetically diverse subclones. Clonal composition rapidly evolved at recurrence, with...

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PMID: 30877103
DOI: 10.1158/0008-5472.can-18-3441

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