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Article

Molecular analysis of an asbestos-exposed Belgian family with a high prevalence of mesothelioma.

Familial cancer - 1 Oct 2018

Hylebos Marieke, Op de Beeck Ken, van den Ende Jenneke, Pauwels Patrick, Lammens Martin, van Meerbeeck Jan P, Van Camp Guy

Abstract excerpt

Familial clustering of malignant mesothelioma (MM) has been linked to the presence of germline mutations in BAP1. However, families with multiple MM patients, without segregating BAP1 mutation were described, suggesting the existence of other predisposing genetic factors. In this study, we report a previously undescribed Belgian family, in which BAP1 was found to be absent in the epithelial malignant mesothelial...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29961174
DOI: 10.1007/s10689-018-0095-1

Genes

BAP1
RBM15
BRD3
EGFR
FAT1
MPL
NOTCH1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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