Article
Association between common genetic variants in pre-microRNAs and gastric cancer risk in Japanese population.
Helicobacter - 1 Dec 2010
Okubo Masaaki, Tahara Tomomitsu, Shibata Tomoyuki, Yamashita Hiromi, Nakamura Masakatsu, Yoshioka Daisuke, Yonemura Joh, Ishizuka Takamitsu, Arisawa Tomiyasu, Hirata Ichiro
Abstract excerpt
BACKGROUND: Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRNA) have been shown to be associated with susceptibility to several human cancers. We evaluated the associations of three SNPs (rs11614913, rs2910164, and rs3746444) in pre-miRNAs (miR-196a2, miR-146a, and miR-499) with the risk of gastric cancer (GC) and peptic ulcer diseases, and with the severity of Helicobacter pylori-induced gastritis...
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