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Article

Development of an isotoxic decision support system integrating genetic markers of toxicity for the implantation of a rectum spacer.

Acta oncologica (Stockholm, Sweden) - 1 Nov 2018

van Wijk Yvonka, Vanneste Ben G L, Jochems Arthur, Walsh Sean, Oberije Cary J, Pinkawa Michael, Ramaekers Bram L T, Vega Ana, Lambin Philippe

Abstract excerpt

INTRODUCTION: Previous studies revealed that dose escalated radiotherapy for prostate cancer patients leads to higher tumor control probabilities (TCP) but also to higher rectal toxicities. An isotoxic model was developed to maximize the given dose while controlling the toxicity level. This was applied to analyze the effect of an implantable rectum spacer (IRS) and extended with a genetic test of normal tissue...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29952681
DOI: 10.1080/0284186X.2018.1484156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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