Article
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease.
American journal of respiratory and critical care medicine - 1 Jul 2016
Hobbs Brian D, Parker Margaret M, Chen Han, Lao Taotao, Hardin Megan, Qiao Dandi, Hawrylkiewicz Iwona, Sliwinski Pawel, Yim Jae-Joon, Kim Woo Jin, Kim Deog Kyeom, Castaldi Peter J, Hersh Craig P, Morrow Jarrett, Celli Bartolome R, Pinto-Plata Victor M, Criner Gerald J, Marchetti Nathaniel, Bueno Raphael, Agustí Alvar, Make Barry J, Crapo James D, Calverley Peter M, Donner Claudio F, Lomas David A, Wouters Emiel F M, Vestbo Jorgen, Paré Peter D, Levy Robert D, Rennard Stephen I, Zhou Xiaobo, Laird Nan M, Lin Xihong, Beaty Terri H, Silverman Edwin K, Cho Michael H
Abstract excerpt
RATIONALE: Chronic obstructive pulmonary disease (COPD) susceptibility is in part related to genetic variants. Most genetic studies have been focused on genome-wide common variants without a specific focus on coding variants, but common and rare coding variants may also affect COPD susceptibility. OBJECTIVES: To identify coding variants associated with COPD. METHODS: We tested nonsynonymous, splice, and stop...
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