Article
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.
Nature communications - 14 Oct 2020
Zhao Xutong, Qiao Dandi, Yang Chaojie, Kasela Silva, Kim Wonji, Ma Yanlin, Shrine Nick, Batini Chiara, Sofer Tamar, Taliun Sarah A Gagliano, Sakornsakolpat Phuwanat, Balte Pallavi P, Prokopenko Dmitry, Yu Bing, Lange Leslie A, Dupuis Josée, Cade Brian E, Lee Jiwon, Gharib Sina A, Daya Michelle, Laurie Cecelia A, Ruczinski Ingo, Cupples L Adrienne, Loehr Laura R, Bartz Traci M, Morrison Alanna C, Psaty Bruce M, Vasan Ramachandran S, Wilson James G, Taylor Kent D, Durda Peter, Johnson W Craig, Cornell Elaine, Guo Xiuqing, Liu Yongmei, Tracy Russell P, Ardlie Kristin G, Aguet François, VanDenBerg David J, Papanicolaou George J, Rotter Jerome I, Barnes Kathleen C, Jain Deepti, Nickerson Deborah A, Muzny Donna M, Metcalf Ginger A, Doddapaneni Harshavardhan, Dugan-Perez Shannon, Gupta Namrata, Gabriel Stacey, Rich Stephen S, O'Connor George T, Redline Susan, Reed Robert M, Laurie Cathy C, Daviglus Martha L, Preudhomme Liana K, Burkart Kristin M, Kaplan Robert C, Wain Louise V, Tobin Martin D, London Stephanie J, Lappalainen Tuuli, Oelsner Elizabeth C, Abecasis Goncalo R, Silverman Edwin K, Barr R Graham, Cho Michael H, Manichaikul Ani
Abstract excerpt
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497 participants from population- and family-based studies, and 8499 individuals from COPD-enriched studies in the NHLBI Trans-Omics for Precision Medicine (TOPMed) Program. We...
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