Article
Association Between Schizophrenia and DNA Demethylase Activity in Human Peripheral Blood Mononuclear Cells.
Clinical laboratory - 1 Jun 2018
Zhang Lili, Pang Bo, Zhang Wenbin, Bai Wei, Yu Weiying, Li Yuanyuan, Hua Wanqing, Li Wenjun, Kou Changgui
Abstract excerpt
BACKGROUND: DNA demethylase is a crucial enzyme in the epigenetic modification and regulation mechanisms of gene transcription. Based on previous assertions that the pathophysiology of schizophrenia is associated with epigenetics, we aimed to explore whether DNA demethylase activity might be related to schizophrenia in northeast China. METHODS: We recruited 25 patients with first-episode schizophrenia and 29...
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