Article
Ikaros family zinc-finger 1 mutation is an independent factor for the poor prognosis of adult B-cell acute lymphoblastic leukemia, and allogeneic hematopoietic stem cell transplantation can improve clinical outcomes.
Bone marrow transplantation - 1 Feb 2019
Tang Shanhao, Shen Hongjie, Qu Changju, Dai Haiping, Zhu Xiaming, Xue Shengli, Ding Zixuan, Lu Jing, Wu Depei, Tang Xiaowen
Abstract excerpt
To investigate the prognosis of patients with adult B-cell acute lymphoblastic leukemia (B-ALL) with Ikaros family zinc-finger 1 (IKZF1) mutation and determine the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in improving the clinical outcome, we detected the IKZF1 mutation and BCR-ABL fusion gene at diagnosis in the bone marrow of 164 adult patients with B-ALL, and analyzed the clinical...
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