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Article

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

25 Jun 2018

Abstract excerpt

Myelodysplastic syndrome (MDS) is a clonal heterogeneous stem cell disorder driven by multiple genetic and epigenetic alterations resulting in ineffective hematopoiesis. MDS has a high frequency of immune suppressors, including myeloid-derived suppressor cells (MDSCs), that collectively result in a poor immune response. MDSCs in MDS patients express CD155 that ligates the T-cell immunoreceptor with immunoglobulin...

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PMID: 29941459
DOI: 10.1182/bloodadvances.2017012369

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