Article

Warfarin-Induced Developmental Toxicity: Insights into Embryogenesis, Teratogenicity, and Molecular Pathways

2026-06-15

Abstract excerpt

Warfarin is a coumarin-derived oral anticoagulant widely used for the prevention and treatment of thromboembolic disorders, particularly in patients with mechanical heart valves. The drug exerts its anticoagulant effect by inhibiting vitamin K epoxide reductase, thereby impairing γ-carboxylation of vitamin K–dependent coagulation factors. Despite its clinical efficacy, warfarin therapy is associated with a narrow...

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Literature Corpus work: ac605e59-a710-567f-83f5-528a7f251246
DOI: 10.20944/preprints202606.1173.v1

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