Article
Identification of the Natural Product Rotihibin A as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling.
Chemistry (Weinheim an der Bergstrasse, Germany) - 27 Aug 2018
Halder Vivek, Oeljeklaus Julian, Heilmann Geronimo, Krahn Jan H, Liu Yanlin, Xiong Yan, Schlicht Markus, Schillinger Jasmin, Kracher Barbara, Ehrmann Michael, Kombrink Erich, Kaschani Farnusch, Kaiser Markus
Abstract excerpt
Bioactive natural products are important starting points for developing chemical tools for biological research. For elucidating their bioactivity profile, biological systems with concise complexity such as cell culture systems are frequently used, whereas unbiased investigations in more complex multicellular systems are only rarely explored. Here, we demonstrate with the natural product Rotihibin A and the plant...
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