Article

Total Synthesis and Chemoproteomics Connect Curcusone Diterpenes with Oncogenic Protein BRAT1

2020-11-23

Abstract excerpt

Natural products are an indispensable source of lifesaving medicine, but natural product-based drug discovery often suffers from scarce natural supply and unknown mode of action. The study and development of anticancer curcusone diterpenes fall into such a dilemma. Meanwhile, many biologically-validated disease targets are considered “undruggable” due to the lack of enzymatic activity and/or predicted small molecu...

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Literature Corpus work: 23b85d53-478f-5890-9bd9-c3d3d17b7a13
DOI: 10.26434/chemrxiv.13271702.v1

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