Role of Calmodulin in Cardiac Disease: Insights on Genotype and Phenotype.

Abstract excerpt

Calmodulin, a protein critically important for the regulation of all major cardiac ion channels, is the quintessential cellular calcium sensor and plays a key role in preserving cardiac electrical stability. Its unique importance is highlighted by the presence of 3 genes in 3 different chromosomes encoding for the same protein and by their extreme conservation. Indeed, all 3 calmodulin (CALM) genes are among the...

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• Arrhythmias, Cardiac
• Calmodulin
• Cardiac electrophysiology and arrhythmias
• Cardiovascular Function and Risk Factors
• Genotype