Article
The ribosomal RPL10 R98S mutation drives IRES-dependent BCL-2 translation in T-ALL.
Leukemia - 1 Feb 2019
Kampen Kim R, Sulima Sergey O, Verbelen Benno, Girardi Tiziana, Vereecke Stijn, Rinaldi Gianmarco, Verbeeck Jelle, Op de Beeck Joyce, Uyttebroeck Anne, Meijerink Jules P P, Moorman Anthony V, Harrison Christine J, Spincemaille Pieter, Cools Jan, Cassiman David, Fendt Sarah-Maria, Vermeersch Pieter, De Keersmaecker Kim
Abstract excerpt
The R98S mutation in ribosomal protein L10 (RPL10 R98S) affects 8% of pediatric T-cell acute lymphoblastic leukemia (T-ALL) cases, and was previously described to impair cellular proliferation. The current study reveals that RPL10 R98S cells accumulate reactive oxygen species which promotes mitochondrial dysfunction and reduced ATP levels, causing the proliferation defect. RPL10 R98S mutant leukemia cells can...
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