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Article

The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.

Leukemia - 1 Mar 2018

Girardi T, Vereecke S, Sulima S O, Khan Y, Fancello L, Briggs J W, Schwab C, de Beeck J Op, Verbeeck J, Royaert J, Geerdens E, Vicente C, Bornschein S, Harrison C J, Meijerink J P, Cools J, Dinman J D, Kampen K R, De Keersmaecker K

Abstract excerpt

Several somatic ribosome defects have recently been discovered in cancer, yet their oncogenic mechanisms remain poorly understood. Here we investigated the pathogenic role of the recurrent R98S mutation in ribosomal protein L10 (RPL10 R98S) found in T-cell acute lymphoblastic leukemia (T-ALL). The JAK-STAT signaling pathway is a critical controller of cellular proliferation and survival. A proteome screen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28744013
DOI: 10.1038/leu.2017.225
PMCID: PMC5669462

Genes

RPL10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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