Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1.

Journal of virology - 1 Sept 2018

Göertz Giel P, McNally Kristin L, Robertson Shelly J, Best Sonja M, Pijlman Gorben P, Fros Jelke J

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has evolved effective mechanisms to counteract the type I interferon (IFN) response. Upon recognition of the virus, cells secrete IFNs, which signal through transmembrane receptors (IFNAR) to phosphorylate STAT proteins (pSTAT). pSTAT dimers are transported into the nucleus by importin-α5 and activate the transcription of IFN-stimulated genes (ISGs),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chikungunya virus
Share to Cysteine Endopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Immunity, Innate

Share to Immunoprecipitation

Share to Interferon Type I

Share to Methyltransferases

Share to STAT1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 29925658
DOI: 10.1128/JVI.01008-18
PMCID: PMC6096799

Genes

STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Methyltransferase-Like Domain of Chikungunya Virus nsP2 Inhibits the Interferon Response by Promoting the Nuclear Export of STAT1.PMID 29925658Read ↗

The C-Terminal Domain of Chikungunya Virus nsP2 Independently Governs Viral RNA Replication, Cytopathicity, and Inhibition of Interferon SignalingSemantic proximity Read ↗

Chikungunya virus nonstructural protein 2 inhibits type I/II interferon-stimulated JAK-STAT signaling.Semantic proximity Read ↗

Novel Mutations in nsP2 Abolish Chikungunya Virus-Induced Transcriptional Shutoff and Make the Virus Less Cytopathic without Affecting Its Replication RatesSemantic proximity Read ↗

Chikungunya Virus nsP2 Impairs MDA5/RIG-I-Mediated Induction of NF-κB Promoter Activation: A Potential Target for Virus-Specific TherapeuticsSemantic proximity Read ↗

G3BP/Rin-Binding Motifs Inserted into Flexible Regions of nsP2 Support RNA Replication of Chikungunya VirusSemantic proximity Read ↗

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation.Semantic proximity Read ↗

Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivoSemantic proximity Read ↗

Chikungunya virus infection disrupts MHC-I antigen presentation via nonstructural protein 2Semantic proximity Read ↗

NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.Semantic proximity Read ↗

NAP1L1 and NAP1L4 binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein is bivalent and requires phosphorylationSemantic proximity Read ↗

Chikungunya Virus-Encoded nsP2, E2 and E1 Strongly Antagonize the Interferon- ¥Signaling PathwaySemantic proximity Read ↗

Suppression of MDA5-mediated antiviral immune responses by NSP8 of SARS-CoV-2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.