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Article

NAP1L1 and NAP1L4 Binding to Hypervariable Domain of Chikungunya Virus nsP3 Protein Is Bivalent and Requires Phosphorylation.

Journal of virology - 26 Jul 2021

Dominguez Francisco, Shiliaev Nikita, Lukash Tetyana, Agback Peter, Palchevska Oksana, Gould Joseph R, Meshram Chetan D, Prevelige Peter E, Green Todd J, Agback Tatiana, Frolova Elena I, Frolov Ilya

Abstract excerpt

Chikungunya virus (CHIKV) is one of the most pathogenic members of the Alphavirus genus in the Togaviridae family. Within the last 2 decades, CHIKV has expanded its presence to both hemispheres and is currently circulating in both Old and New Worlds. Despite the severity and persistence of the arthritis it causes in humans, no approved vaccines or therapeutic means have been developed for CHIKV infection....

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Identifiers

PMID: 34076483
DOI: 10.1128/JVI.00836-21
PMCID: PMC8312869

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