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Article

Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment.

PLoS genetics - 1 Jun 2018

Burns Michael B, Montassier Emmanuel, Abrahante Juan, Priya Sambhawa, Niccum David E, Khoruts Alexander, Starr Timothy K, Knights Dan, Blekhman Ran

Abstract excerpt

Variation in the gut microbiome has been linked to colorectal cancer (CRC), as well as to host genetic variation. However, we do not know whether, in addition to baseline host genetics, somatic mutational profiles in CRC tumors interact with the surrounding tumor microbiome, and if so, whether these changes can be used to understand microbe-host interactions with potential functional biological relevance. Here,...

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Identifiers

PMID: 29924794
DOI: 10.1371/journal.pgen.1007376
PMCID: PMC6028121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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