Metagenomic analysis of formalin-fixed paraffin-embedded tumor and normal mucosa reveals differences in the microbiome of colorectal cancer patients

Abstract excerpt

An increased risk of developing colorectal cancer (CRC) and other types of tumor is associated to Lynch syndrome (LS), an inherited condition caused by germline mutations in mismatch repair genes. We selected a cohort of LS patients that had developed CRC and had undergone surgical resection. Formalin-fixed paraffin embedded (FFPE) tissue blocks from matched colorectal and normal mucosa were used for genomic DNA...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Colorectal Cancer Screening and Detection
• Share to Genetic factors in colorectal cancer
• Share to Molecular Biology Techniques and Applications