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Article

Prevalence of ALK gene alterations among the spectrum of plexiform spitzoid lesions.

Journal of the American Academy of Dermatology - 1 Oct 2018

Saraggi Deborah, Salmaso Roberto, Zamuner Carolina, Munari Giada, Lanza Cristiano, Alaibac Mauro Salvatore, Bassetto Franco, Rugge Massimo, Montesco Maria Cristina, Cerroni Lorenzo, Fassan Matteo

Abstract excerpt

BACKGROUND: ALK receptor tyrosine kinase gene (ALK) rearrangements have been described in spitzoid lesions with a plexiform growth pattern. OBJECTIVE: To investigate the prevalence of ALK alterations in a large series of spitzoid lesions. METHODS: ALK immunohistochemical and fluorescence in situ hybridization analyses of 78 spitzoid plexiform lesions including 41 Spitz nevi, 29 atypical Spitz tumors (ASTs), and 8...

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Source

Identifiers

PMID: 29920315
DOI: 10.1016/j.jaad.2018.06.018

Genes

ALK
BRAF
DCTN1
TPM3

Variants

Provenance

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