Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split Inteins

19 Jun 2018

Abstract excerpt

Cell targeting protein toxins have gained increasing interest for cancer therapy aimed at increasing the therapeutic window and reducing systemic toxicity. Because recombinant expression of immunotoxins consisting of a receptor-binding and a cell-killing moiety is hampered by their high toxicity in a eukaryotic production host, most applications rely on recombinant production of fusion proteins consisting of an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical and Structural Characterization
Share to Monoclonal and Polyclonal Antibodies Research
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29920062
DOI: 10.1021/acschembio.8b00222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation of Potent Anti-HER1/2 Immunotoxins by Protein Ligation Using Split InteinsPMID 29920062Read ↗

The Evolution of Intein-Based Affinity Methods as Reflected in 30 years of Patent HistorySemantic proximity Read ↗

Improved protein splicing using embedded split inteinsSemantic proximity Read ↗

Regulation of protein activity with small-molecule-controlled inteins.Semantic proximity Read ↗

Development of a screening system for inteins active in protein splicing based on intein insertion into the LacZα-peptide.Semantic proximity Read ↗

Unprecedented rates and efficiencies revealed for new natural split inteins from metagenomic sources.Semantic proximity Read ↗

Engineered Bifunctional Proteins for Targeted Cancer Therapy: Prospects and ChallengesSemantic proximity Read ↗

Traceless protein splicing utilizing evolved split inteins.Semantic proximity Read ↗

Characterization of a self-splicing mini-intein and its conversion into autocatalytic N- and C-terminal cleavage elements: facile production of protein building blocks for protein ligation.Semantic proximity Read ↗

A redox trap to augment the intein toolbox.Semantic proximity Read ↗

Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells.Semantic proximity Read ↗

Challenges in Expression and Purification of Functional Fab Fragments in E. coli: Current Strategies and PerspectivesSemantic proximity Read ↗

Disulfide-compatible phage-assisted continuous evolution in the periplasmic spaceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.